Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain
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چکیده
منابع مشابه
Visualization of monoamine oxidase in human brain.
11973 Monoamine oxidase (MAO; EC: 1.4.3.4) is a flavin containing enzyme which exists in two subtypes, MA0 A and MA0 B. MA0 A and B are different gene products and they also differ in their substrate and inhibitor selectivities and their cellular localizations. In human brain MA0 B predominates (B:A = 4:l) and is largely compartmentalized in cell bodies of serotonergic neurons and in glia. Many...
متن کاملThe relationship between human monoamine oxidase A and B
Monoamine oxidase (EC 1.4.3.4) exists in at least two forms (termed type A and type B) with different substrate and inhibitor specificities (Johnston, 1968; Knoll & Magyar, 1972). Amine neurotransmitters are among a wide range of substrates (Blaschko, 1974) and abnormalities of monoamine oxidase activity may therefore contribute to neurological disease. Most studies of such diseases have looked...
متن کاملHuman Plasma Monoamine Oxidase
Although this human plasma enzyme was shown (1) to have certain characteristics in common with plasma amine oxidases from other mammals (2-6), it could be distinguished from these other plasma enzymes by its substrate specificity. During studies relating to the substrate specificity of the human enzyme, the oxidation of aliphatic amines was noted to have a number of distinctive kinetic features...
متن کاملHuman Plasma Monoamine Oxidase
Amine oxidases that occur in the plasma of mammals have been intensively studied in recent years (l-8). The ability of human plasma and serum to convert benzylamine to benzaldehyde has recently been demonstrated (9). Evidence has been presented to show that this enzymatic activity is different from other human plasma enzymes that catalyze the oxidation of amines (i.e. ceruloplasmin and diamine ...
متن کاملParkinsonism induced by a monoamine oxidase inhibitor.
A parkinsonian syndrome developed 5 weeks after administration of phenelzine in a 42 year old woman with major depressive illness. Discontinuation of this agent resulted in gradual disappearance of the extrapyramidal syndrome. Possible underlying mechanisms for this unusual case are discussed.
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ژورنال
عنوان ژورنال: Alzheimer's Research & Therapy
سال: 2017
ISSN: 1758-9193
DOI: 10.1186/s13195-017-0253-y